You are here: Home » Resources » Bibliography


1. Akinbami L. Asthma prevalence, healthcare use and mortality. United States 2003 - 2005, CDC National Center for Health Statistics [Akinbami]. 2006.

2. Buckley ST, Ehrhardt C. The receptor for advanced glycation end products (RAGE) and the lung. J Biomed Biotechnol. 2010;2010:917108.

3. DeChristopher, L.R. "Consumption of Fructose and High Fructose Corn Syrup: Is Fructositis Triggered Bronchitis, Asthma, & Auto-immune Reactivity Merely a Side Bar in the Etiology of Metabolic Syndrome II (to Be Defined)? – Evidence and a Hypothesis." Thesis. New York Medical College, 2012. Print. paper.html

4. DeFrances C, Cullen K, Kozak L. National hospital discharge survey: 2005 annual summary with detailed diagnosis and procedure data. National Center for Health Statistics [DeFrances]. 2007;Vital Health Statistics 12:165.

5. Beyer PL, Caviar EM, McCallum RW. Fructose intake at current levels in the united states may cause gastrointestinal distress in normal adults. J Am Diet Assoc. 2005;105:1559-1566.

6. Foell D, Kucharzik T, Kraft M, Vogl T, Sorg C, Domschke W, Roth J. Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease. Gut. 2003;52:847-853.

7. Foell D, Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum. 2004;50:3762-3771.

8. Helliwell PA, Richardson M, Affleck J, Kellett GL. Stimulation of fructose transport across the intestinal brush-border membrane by PMA is mediated by GLUT2 and dynamically regulated by protein kinase C. Biochem J. 2000;350 Pt 1:149-154.

9. Hoekstra JH, van den Aker JH, Kneepkens CM, Stellaard F, Geypens B, Ghoos YF. Evaluation of 13CO2 breath tests for the detection of fructose malabsorption. J Lab Clin Med. 1996;127:303-309.

10. Hoekstra JH, van Kempen AA, Bijl SB, Kneepkens CM. Fructose breath hydrogen tests. Arch Dis Child. 1993;68:136-138.

11. Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, Neurath MF, Slattery T, Beach D, McClary J, Nagashima M, Morser J, Stern D, Schmidt AM. RAGE mediates a novel proinflammatory axis: A central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999;97:889-901.

12. Hofmann SM, Dong HJ, Li Z, Cai W, Altomonte J, Thung SN, Zeng F, Fisher EA, Vlassara H. Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes. 2002;51:2082-2089.

13. Kellett GL, Brot-Laroche E. Apical GLUT2: A major pathway of intestinal sugar absorption. Diabetes. 2005;54:3056-3062.

14. Kellett GL, Helliwell PA. The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane. Biochem J. 2000;350 Pt 1:155-162.

15. Leturque A, Brot-Laroche E, Le Gall M. GLUT2 mutations, translocation, and receptor function in diet sugar managing. Am J Physiol Endocrinol Metab. 2009;296:E985-92.

16. Lin L, Park S, Lakatta EG. RAGE signaling in inflammation and arterial aging. Front Biosci. 2009;14:1403-1413.

17. Laukoetter MG, Nava P, Nusrat A. Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol. 2008;14:401-407.

18. Morbini P, Villa C, Campo I, Zorzetto M, Inghilleri S, Luisetti M. The receptor for advanced glycation end products and its ligands: A new inflammatory pathway in lung disease? Mod Pathol. 2006;19:1437-1445.

19. Qian BF, Wahl SM. TGF-beta can leave you breathless. Curr Opin Pharmacol. 2009;9:454-461.

20. Riby JE, Fujisawa T, Kretchmer N. Fructose absorption. Am J Clin Nutr. 1993;58:748S-753S.

21. Rumessen JJ, Gudmand-Hoyer E. Functional bowel disease: Malabsorption and abdominal distress after ingestion of fructose, sorbitol, and fructose-sorbitol mixtures. Gastroenterology. 1988;95:694-700.

22. Rumessen JJ. Fructose and related food carbohydrates. sources, intake, absorption, and clinical implications. Scand J Gastroenterol. 1992;27:819-828.

23. Suarez G, Rajaram R, Oronsky AL, Gawinowicz MA. Nonenzymatic glycation of bovine serum albumin by fructose (fructation). comparison with the maillard reaction initiated by glucose. J Biol Chem. 1989;264:3674-3679.

24. Trends in asthma morbidity and mortality. American Lung Association. 2007; Epidemiology & Statistics Unit, Research and Program Services. and

25. Truswell AS, Seach JM, Thorburn AW. Incomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose. Am J Clin Nutr. 1988;48:1424-1430.

26. Urbonaviciute V, Voll RE. High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus. J Intern Med. 2011;270:309-318.

27. Vos MB, Kimmons JE, Gillespie C, Welsh J, Blanck HM. Dietary fructose consumption among US children and adults: The third national health and nutrition examination survey. Medscape J Med. 2008;10:160.

28. Wolf R, Mascia F, Dharamsi A, Howard OM, Cataisson C, Bliskovski V, Winston J, Feigenbaum L, Lichti U, Ruzicka T, Chavakis T, Yuspa SH. Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med. 2010;2:61ra90.

29. Wu L, Ma L, Nicholson LF, Black PN. Advanced glycation end products and its receptor (RAGE) are increased in patients with COPD. Respir Med. 2011;105:329-336.

30. Yan SF, Ramasamy R, Schmidt AM. Soluble RAGE: Therapy and biomarker in unraveling the RAGE axis in chronic disease and aging. Biochem Pharmacol. 2010;79:1379-1386.

31. Yilmaz Y, Yonal O, Eren F, Atug O, Hamzaoglu HO. Serum levels of soluble receptor for advanced glycation endproducts (sRAGE) are higher in ulcerative colitis and correlate with disease activity. J Crohns Colitis. 2011;5:402-406.

32. Yu LC. Intestinal epithelial barrier dysfunction in food hypersensitivity. J Allergy (Cairo). 2012;2012:596081.

33. USDA National Nutrient Database for Standard Reference, Release 24.  Nutrient Data Laboratory Home Page. Available at: Accessed 01/15, 2012.

34. Trends in asthma morbidity and mortality. American Lung Association. 2007; Epidemiology & Statistics Unit, Research and Program Services. and


36. BeMiller JN. One hundred years of commercial food carbohydrates in the united states. J Agric Food Chem. 2009;57:8125-8129.

37. Haley S, Toasa J, Jerardo A. Sugar and sweeteners outlook. United States Department of Agriculture [A Report from the Economic Research Service]. 2008;SSS:253.

38. Takeuchi M, Iwaki M, Takino J, Shirai H, Kawakami M, Bucala R, Yamagishi S. Immunological detection of fructose-derived advanced glycation end-products. Lab Invest. 2010;90:1117-1127.

39. Mannino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, Redd SC. Surveillance for asthma--United States, 1980-1999. MMWR Surveill Summ. 2002 Mar 29;51(1):1-13. PubMed PMID: 12420904." target="_blank"

40. Xue J, Rai V, Singer D, Chabierski S, Xie J, Reverdatto S, Burz DS, Schmidt AM, Hoffmann R, Shekhtman A. Advanced glycation end product recognition by the receptor for AGEs. Structure. 2011;19:722-732.

41. Cummings BP, Stanhope KL, Graham JL, Evans JL, Baskin DG, Griffen SC, Havel PJ. Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: Amelioration by the antioxidant, alpha-lipoic acid. Am J Physiol Regul Integr Comp Physiol. 2010;298:R1343-50.

42. Dekker MJ, Su Q, Baker C, Rutledge AC, Adeli K. Fructose: A highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2010;299:E685-94.

43. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest. 2009;119:1322-1334.

44. Gibson PR, Newnham E, Barrett JS, Shepherd SJ, Muir JG. Review article: Fructose malabsorption and the bigger picture. Aliment Pharmacol Ther. 2007;25:349-363.

45. Jones HF, Butler RN, Brooks DA. Intestinal fructose transport and malabsorption in humans. Am J Physiol Gastrointest Liver Physiol. 2011;300:G202-6.

46. Berg JM, Tymoczko JL, Stryer L. Biochemistry. 5th edition. New York: W H Freeman; 2002. Figure 16.15 Fructose Metabolism.

47. Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim C, Wu X, Yu Y, Amlal H, Seidler U, Zuo J, Soleimani M. Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. J Biol Chem. 2009;284:5056-5066.

48. Le MT, Frye RF, Rivard CJ, Cheng J, McFann KK, Segal MS, Johnson RJ, Johnson JA. Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. Metabolism. 2012 May;61(5):641-51. Epub 2011 Dec 5. PubMed PMID: 22152650; PubMed Central PMCID: PMC3306467.

49. Aeberli I, Hochuli M, Gerber PA, Sze L, Murer SB, Tappy L, Spinas GA, Berneis K. Moderate Amounts of Fructose Consumption Impair Insulin Sensitivity in Healthy Young Men: A randomized controlled trial. Diabetes Care. 2012 Aug 28. [Epub ahead of print] PubMed PMID: 22933433.

50. Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T, Chen G, Fong TH, Lee V, Menorca RI, Keim NL, Havel PJ. Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women. J Clin Endocrinol Metab. 2011 Oct;96(10):E1596-605. Epub 2011 Aug 17. PubMed PMID: 21849529; PubMed Central PMCID: PMC3200248.

51. Jones HF, Butler RN, Brooks DA. Intestinal fructose transport and malabsorption in humans. Am J Physiol Gastrointest Liver Physiol. 2011;300:G202-6.

52. Gibson PR, Newnham E, Barrett JS, Shepherd SJ, Muir JG. Review article: Fructose malabsorption and the bigger picture. Aliment Pharmacol Ther. 2007;25:349-363.

53.Page KA, Chan O, Arora J, Belfort-Deaguiar R, Dzuira J, Roehmholdt B, Cline GW, Naik S, Sinha R, Constable RT, Sherwin RS. Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. JAMA. 2013 Jan 2;309(1):63-70. doi: 10.1001/jama.2012.116975. PubMed PMID: 23280226.

54. Gomara RE, Halata MS, Newman LJ, Bostwick HE, Berezin SH, Cukaj L, See MC, Medow MS. Fructose intolerance in children presenting with abdominal pain. J Pediatr Gastroenterol Nutr. 2008 Sep;47(3):303-8. doi: 10.1097/MPG.0b013e318166cbe4. PubMed PMID: 18728526.

55. Jones HF, Burt E, Dowling K, Davidson G, Brooks DA, Butler RN. Effect of age on fructose malabsorption in children presenting with gastrointestinal symptoms. J Pediatr Gastroenterol Nutr. 2011 May;52(5):581-4. doi: 10.1097/MPG.0b013e3181fd1315. PubMed PMID: 21502829.